You can partner with a company that uses your own cell lines with cell culture supernatant. The supernatant is the medium where the cells grow and is designed to ensure success. In addition, they may centrifugate the supernatant to eliminate floating cells of debris, which leaves the supernatant behind.
Purification and Downstream Processing
When you work with a company that produces monoclonal antibodies or recombinant protein products, they perform purification and downstream processing. If you have an existing purification process, they can use it, or they can develop their own purification process for your cell culture supernatant and proteins. In addition, they can use different types of protein, including monoclonal antibodies. They can use recombinant proteins, antibody fragments, and derivatives. This type of company offers all of the services you need, from technology transfer and process development to process evaluation and validation.
Automated Culture Systems
In addition, a cell culture company offers AcuSyst to help with your monoclonal antibody needs. They can offer single-use disposable cartridges that shorten the amount of time needed for cleaning and labor, and their processes are scalable because they can add cartridges as needed. They also manufacture the proteins continuously, harvest them, and then consolidate the upstream process. They use cell culture supernatant to improve the quality of the cell cultures, using processes that reduce the chances of contamination and the need for labor. This type of company uses the latest technology, so they can automate monitoring and control, which ensures that the cells are reproducible.
